Research Articles
Testosterone: More Is Not Always Better – 2009 – Journal of Clinical Endocrinology and Metabolism
Having conducted population-based studies on the relationship of sex steroid levels to bone mass in Rochester,Minnesota for many years, I have been struck by just how often male members of the medical staff at our institution who participate in these studies inquire about their testosterone level. Discovering that they happen to be in the top…
Testosterone and Growth Hormone Improve Body Composition and Muscle in Men 2009
Alterations in body composition, physical function, and substrate metabolism occur with advancing age. Loss of skeletal muscle mass (sarcopenia) (1, 2) contributes to declines in muscle strength and function along with diminished quality of life (3). In the Baltimore Longitudinal Aging Study, quadriceps strength decreased about 30% between 50 –70 yr of age (4). In…
Recent Advances in Thyroid Hormone Regulation Toward a New Paradigm for Optimal Diagnosis and Treatment 2017
In thyroid health, the pituitary hormone thyroid-stimulating hormone (TSH) raises glandular thyroid hormone production to a physiological level and enhances formation and conversion of T4 to the biologically more active T3. Overstimulation is limited by negative feedback control. In equilibrium defining the euthyroid state, the relationship between TSH and FT4 expresses clusters of genetically determined,…
Relation of Testosterone Normalization to Mortality and Myocardial Infarction in Men With Previous Myocardial Infarction 2019
The effect of normalization of serum testosterone levels with testosterone replacement therapy (TRT) in patients with a prior history of myocardial infarction (MI) is unknown. The objective of this study was to determine the incidence of recurrent MI and all-cause mortality in subjects with a history of MI and low total testosterone (TT) with and…